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Eruptive xanthomas associated with olanzapine use.

Howard Y Chang¹, Todd W Ridky, Alexandra B Kimball

¹Department of Dermatology, Program in Epithelial Biology, Stanford University School of Medicine, Stanford, Calif. 94305, USA.

Archives of Dermatology

|August 20, 2003

Summary

Atypical antipsychotic olanzapine can cause severe dyslipidemia, including eruptive xanthomas, in some patients. Dermatologists should monitor high-risk individuals for metabolic changes during treatment.

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Area of Science:

Dermatology
Endocrinology
Pharmacology

Background:

Atypical antipsychotics, like olanzapine, are increasingly used for psychogenic dermatoses.
Known side effects include mild hyperglycemia and hypertriglyceridemia.
Metabolic effects and skin impacts are not fully understood.

Observation:

Three patients developed eruptive xanthomas after initiating olanzapine.
One patient had relative insulin insufficiency.
These cases suggest a link between olanzapine and severe dyslipidemia.

Findings:

Olanzapine use is associated with severe dyslipidemia in susceptible individuals.
Eruptive xanthomas can manifest as a consequence of this metabolic disturbance.
The findings highlight a potential dermatologic manifestation of olanzapine's metabolic effects.

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Implications:

Dermatologists must be aware of the risk of dyslipidemia with olanzapine.
Periodic metabolic monitoring is crucial for high-risk patients.
This underscores the importance of a multidisciplinary approach in managing patients on atypical antipsychotics.