Where do perseverations come from?
Related Experiment Video
Updated: Sep 20, 2026

Signal Attenuation as a Rat Model of Obsessive Compulsive Disorder
Published on: January 9, 2015
Elise Caccappolo-van Vliet1, Michele Miozzo, Karen Marder
1Cognitive Neuroscience Division, Taub Institute for Research in Alzheimer's Disease and the Aging Brain, New York, NY, USA.
Abstract:
RB, a patient with probable Alzheimer's disease, makes continuous perseverations of single letters when writing (e.g. fruit-->fruuit), particularly on high frequency letters. An analysis of her errors reveals that her perseverations do not reflect letter substitutions or transpositions, nor do they suggest difficulty with geminates. No continuous perseverations were found in oral production, in graphic and simple motor tasks, and in oral spelling. RB's data do not support an attention deficit as the basis of her continuous perseverations. It is proposed that a deficit at the level of abstract letter representations is the source of RB's perseverations. The implications of this conclusion for accounts of perseveration and of spelling models are discussed.
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