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Traceless solid phase synthesis of 2-substituted pyrimidines using an 'off-the-shelf' chlorogermane-functionalised
Alan C Spivey1, Ratnasothy Srikaran, Christopher M Diaper
1Department of Chemistry, University of Sheffield, Brook Hill, Sheffield, Yorkshire, UK S3 7HF. a.c.spivey@imperial.ac.uk
Organic & Biomolecular Chemistry
|August 21, 2003
Abstract:
The parallel solid phase synthesis of an 18-member library of 2-substituted pyrimidines is described using a chlorogermane-functionalised resin. The success of the key Pinner-type condensations between a resin-bound enaminone and an array of amidine hydrochlorides highlights the stability of arylgermane linkers (cf. arylsilanes) towards strongly basic/nucleophilic conditions.