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Related Experiment Videos

Evolution of focal and diffuse magnetisation transfer abnormalities in multiple sclerosis.

Cornelia Laule1, Irene M Vavasour, Kenneth P Whittall

  • 1Dept. of Physics & Astronomy, University of British Columbia, 2211 Wesbrook Mall, Vancouver BC, V6T 2B5, Canada. claule@physics.ubc.ca

Journal of Neurology
|August 21, 2003
PubMed
Summary

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Developing Topics.

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Magnetisation transfer (MT) imaging reveals progressive white matter changes in multiple sclerosis (MS). Normal-appearing white matter MT ratio decreases over time, predicting new lesion formation.

Area of Science:

  • Neuroimaging
  • Biophysics
  • Neurology

Background:

  • Conventional MRI may not detect early white matter abnormalities in multiple sclerosis (MS).
  • Magnetisation transfer (MT) imaging offers indirect insights into tissue structure changes.
  • Understanding the evolution of MT changes is crucial for tracking MS progression.

Purpose of the Study:

  • To investigate the longitudinal changes in MT imaging metrics within normal-appearing white matter (NAWM) and MS lesions.
  • To correlate MT changes with disease duration and the appearance of new lesions.
  • To assess MT ratio (MTR) recovery in lesions based on pre-lesion MTR changes.

Main Methods:

  • Serial MT imaging examinations were performed on 9 MS patients and age-matched controls.

Related Experiment Videos

  • The mean MT ratio (MTR) in NAWM was analyzed in relation to time since first clinical presentation.
  • MTR changes were monitored before and after the appearance of new lesions on conventional MRI.

    • Main Results:

    • NAWM MTR showed a significant linear decrease over time, correlating strongly with disease duration (-0.16%/year).
    • MTR began to decrease 6-12 months before new lesion appearance, with a steeper decline 2-6 months prior.
    • Lesions with pre-lesion MTR decrease exhibited poorer MTR recovery.

    Conclusions:

    • NAWM MTR in MS patients declines progressively from disease onset.
    • Accelerated MTR decrease in focal areas precedes lesion manifestation on conventional MRI.
    • MT imaging can detect early microstructural changes in MS, aiding in understanding disease evolution and lesion development.