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Depletion of Specific Cell Populations by Complement Depletion
06:17

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Published on: February 5, 2010

[B-cell depletion in the treatment of rheumatoid arthritis]

Eugen Feist1, Gerd-R Burmester, Thomas Dörner

  • 1Medizinische Klinik mit Schwerpunkt Rheumatologie und Klinische Immunologie, Universitätsklinikum Charité Humboldt-Universität zu Berlin, Berlin, Germany. eugen.feist@charite.de

Zeitschrift Fur Rheumatologie
|August 21, 2003
PubMed

New strategies including the blockade of TNFalpha showed excellent therapeutic effects even in so far refractory rheumatic diseases. Moreover, these approaches provided us with important informations about the pathogenic role of the mediators involved and distinct autoimmune cellular subsets. Here, we discuss recent data of a temporary B cell depletion using a monoclonal anti-CD20 antibody in the therapeutic arsenal of rheumatoid arthritis.

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