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Related Experiment Videos

Trazodone for erectile dysfunction: a systematic review and meta-analysis.

H A Fink1, R MacDonald, I R Rutks

  • 1Geriatric Research Education and Clinical Center, Section of General Internal Medicine, VA Medical Center, Minneapolis, USA. howard.fink@med.va.gov

BJU International
|August 22, 2003
PubMed
Summary

Trazodone may offer benefits for erectile dysfunction (ED), particularly at higher doses and for psychogenic ED. Further research is recommended to confirm its efficacy and safety in specific patient groups.

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Area of Science:

  • Pharmacology
  • Urology
  • Clinical Trials

Background:

  • Erectile dysfunction (ED) is a common condition affecting men's health.
  • Trazodone, an antidepressant, has been explored for its potential in treating ED.

Purpose of the Study:

  • To conduct a meta-analysis evaluating the efficacy and safety of trazodone for erectile dysfunction.
  • To identify patient subgroups and optimal dosages for trazodone treatment in ED.

Main Methods:

  • Systematic review and meta-analysis of randomized controlled trials.
  • Inclusion criteria: men with ED, trazodone vs. control, >7 days duration.
  • Data extraction and quality assessment by two independent reviewers.

Main Results:

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  • Six trials (396 men) met criteria; populations were heterogeneous.
  • Two of six trials showed statistically significant improvement with trazodone.
  • Pooled analysis: trazodone (37%) vs. placebo (20%) for positive response (not significant).
  • Potential benefit in psychogenic ED and at higher doses (150-200 mg/day).
  • Adverse events included dry mouth, sedation, dizziness, and fatigue; no significant increase vs. placebo.

Conclusions:

  • Trazodone may be beneficial for men with ED, especially those with psychogenic ED and at higher doses.
  • High-quality trials are needed to compare trazodone with placebo and other treatments in specific ED populations.