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Ovarian hyperstimulation syndrome: strategies for prevention
Dehan Chen1, Lynn Burmeister, Dan Goldschlag
1The Center for Reproductive Medicine and Infertility, Weill Cornell Medical College, 505 East 70th Street, HMT-340, New York, NY 10021, USA.
Reproductive Biomedicine Online
|August 22, 2003
Summary
Ovarian hyperstimulation syndrome (OHSS) is a serious complication of ovarian stimulation. This review covers established and novel strategies to prevent OHSS, focusing on physiological mechanisms.
Area of Science:
- Reproductive Endocrinology
- Obstetrics and Gynecology
- Clinical Pharmacology
Background:
- Ovarian hyperstimulation syndrome (OHSS) is a significant iatrogenic complication.
- OHSS arises from exaggerated response during controlled ovarian stimulation.
- Understanding OHSS pathogenesis is crucial for effective prevention.
Purpose of the Study:
- To review traditional and novel strategies for preventing OHSS.
- To discuss the physiological basis of OHSS prevention techniques.
- To present institutional experience with OHSS management.
Main Methods:
- Review of established OHSS prevention techniques (e.g., dose reduction, coasting, cryopreservation).
- Summary of investigative strategies (e.g., follicular aspiration, in-vitro oocyte maturation, GnRH agonist trigger, volume expanders).
- Analysis of internal institutional experience with OHSS.
Main Results:
- Various methods exist to mitigate OHSS risk.
- Techniques range from modifying stimulation protocols to advanced interventions.
- Physiological understanding underpins current preventative approaches.
Conclusions:
- Multiple strategies can be employed to prevent OHSS.
- The choice of prevention depends on clinical context and understanding of OHSS pathophysiology.
- Continued research into OHSS prevention is warranted.