Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Molecular imaging with endogenous substances.

Klaes Golman1, Jan H Ardenkjaer-Larsen, J Stefan Petersson

  • 1Amersham Health Research and Development AB, Medeon, SE-205 12 Malmö, Sweden. klaes.golman@amersham.com

Proceedings of the National Academy of Sciences of the United States of America
|August 22, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Dynamic <sup>13</sup>C-MRI of Branched-Chain Amino Acid Metabolism Using Hyperpolarized [1-<sup>13</sup>C]2-Ketoisocaproate: A Multiband IDEAL Spiral Approach in Rodents and Pigs.

Magnetic resonance in medicine·2025
Same author

Incidence of cerebral small vessel disease-related MR markers in the Swedish general population 'Good Aging in Skåne'(GÅS) study.

Journal of neurology·2024
Same author

Development of Dissolution Dynamic Nuclear Polarization of [<sup>15</sup> N<sub>3</sub> ]Metronidazole: A Clinically Approved Antibiotic.

Angewandte Chemie (International ed. in English)·2023
Same author

Is good muscle function a protective factor for early signs of knee osteoarthritis after anterior cruciate ligament reconstruction? The SHIELD cohort study protocol.

Osteoarthritis and cartilage open·2022
Same author

Haemophilia A and B - evaluation of the Swedish prophylactic regimen by magnetic resonance imaging.

Haemophilia : the official journal of the World Federation of Hemophilia·2022
Same author

Postprandial triglyceride levels rather than fat distribution may reflect early signs of disturbed fat metabolism in Iraqi immigrants.

Lipids in health and disease·2022
Same journal

Chemotactic self-organization captures the dynamics of mammalian hair follicle patterning.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same journal

Tomographic imaging of superconducting order using particle-hole interference.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same journal

Inhibitory potential of autologous neutralizing antibodies sets quantitative limits on the rebound-competent HIV-1 reservoir.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same journal

Inferring epidemiological parameters under an infectious phylogeography model with visitor dynamics.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same journal

Analytical modeling for suction cup designs for skin-interfaced wearable devices.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same journal

Improving cell-free metabolism through direct integration of artificial respiratory chains.

Proceedings of the National Academy of Sciences of the United States of America·2026
See all related articles

Dynamic nuclear polarization hyperpolarized 13C-labeled urea for subsecond 13C MRI. This technique achieved high-resolution 13C angiography in rats, demonstrating potential for advanced medical imaging.

Area of Science:

  • Medical Imaging
  • Biophysics
  • Nuclear Magnetic Resonance

Background:

  • Dynamic nuclear polarization (DNP) enhances nuclear spin polarization.
  • Hyperpolarized nuclei, like 13C, enable faster MRI scans.
  • Endogenous substances can be hyperpolarized for in vivo studies.

Purpose of the Study:

  • To assess the feasibility of subsecond 13C MRI using hyperpolarized urea.
  • To evaluate 13C angiography with hyperpolarized [13C]urea in a rat model.
  • To explore the potential of DNP-enhanced MRI for perfusion studies.

Main Methods:

  • Achieved 10% polarization in 100 mM aqueous [13C]urea solution using DNP.
  • Determined in vivo 13C T1 relaxation time of urea (~20 s).
  • Acquired high-resolution (approx. 1-mm) 13C MRI at sub-second scan times (240 ms) post-injection in rats.

Related Experiment Videos

Main Results:

  • Demonstrated 13C angiography with a signal-to-noise ratio of ~275 in ~0.25 s.
  • Achieved subsecond imaging of hyperpolarized [13C]urea in vivo.
  • Confirmed the long T1 relaxation time of hyperpolarized urea suitable for imaging.

Conclusions:

  • DNP enables rapid 13C MRI of endogenous substances like urea.
  • Subsecond 13C angiography is feasible with hyperpolarized [13C]urea.
  • This technique offers potential for improved spatial/temporal resolution in perfusion imaging.