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Study of stereoselective synthesis of (+/-)-neocnidilide
Xiao-Zhen Jiao1, Ping Xie, Lian-Suo Zu
1Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.
Journal of Asian Natural Products Research
|August 23, 2003
Abstract:
Neocnidilide 1, isolated from Apium graveleues L (Umbelliferae), has shown activity to inhibit the growth of mycotoxin-producing fungi. An efficient method for the synthesis of the racemic neocnidilide by the stereoselective reaction of hemiacetal 6 with n-BuMgBr has been developed.