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Asymmetric synthesis of (alpha-amino)phosphonic acid amphiphiles using chiral P-H spirophosphoranes
Christophe Déjugnat1, Guita Etemad-Moghadam, Isabelle Rico-Lattes
1Laboratoire des Interactions Moléculaires et Réactivité Chimique et Photochimique, CNRS 5623, Université Paul Sabatier, 118 route de Narbonne, 31062 Toulouse cedex 04, France.
Chemical Communications (Cambridge, England)
|August 23, 2003
Abstract:
Chiral P-H spirophosphoranes reacted with long-chain prochiral aldimines and, after selective hydrolysis, afforded (alpha-amino)phosphonic acid amphiphiles in both enantiopure forms.