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Relation between serum uric acid and angiographically defined coronary artery disease in postmenopausal women
1First Department of Internal Medicine, Tottori University School of Medicine, Yonago, Japan.
Insights
In postmenopausal women, higher serum uric acid (UA) levels correlate with severe coronary artery stenosis. Elevated UA may indicate significant coronary artery disease in this demographic.
Area of Science:
- Cardiovascular Medicine
- Biochemistry
Background:
- Elevated serum uric acid (UA) is linked to cardiovascular disease.
- The role of UA as an independent coronary risk factor requires further investigation, particularly in postmenopausal women.
Purpose of the Study:
- To investigate the association between serum uric acid levels and the severity of coronary artery stenosis in postmenopausal women and men.
Main Methods:
- Serum UA levels were measured in 40 postmenopausal women and 57 men undergoing coronary angiography.
- Participants were matched for age and body mass index (BMI).
- Correlation analysis was performed between UA levels and the number of stenosed coronary arteries and serum triglyceride levels.
Main Results:
- In postmenopausal women, mean UA levels increased with the number of coronary arteries showing >= 50% stenosis.
- UA levels were significantly higher in women with three-vessel disease compared to those without stenosis (p < 0.05).
- No significant changes in UA levels were observed in men. UA increase in women correlated with triglyceride levels (p < 0.05).
Conclusions:
- Serum uric acid may not be an independent coronary risk factor.
- Elevated UA levels in postmenopausal women could indicate severe coronary artery stenosis.
- Further research is needed to clarify the role of UA in cardiovascular disease pathogenesis.
Abstract:
Serum uric acid (UA) levels were studied in 40 postmenopausal women and 57 men, almost matched for age and body mass index (BMI) and undergoing coronary angiography. For women, the mean value of UA increased as the number of coronary arteries with > or = 50% stenosis increased. Its value was significantly higher (p < 0.05) in a three-vessel disease group than that of a group without stenosis. No significant changes were seen in men. However, the increase in UA for postmenopausal women was statistically (p < 0.05) correlated with serum triglyceride levels. Possibly, UA is not an independent coronary risk factor. However, elevated UA levels may suggest the prevalence of severe coronary artery stenosis for postmenopausal women.