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Related Experiment Videos

Coat colour changes associated with cabergoline administration in bitches.

C Gobello1, G Castex, G Broglia

  • 1Small Animal Clinics, Faculty of Veterinary Sciences (CC 296), National University of La Plata, Argentina.

The Journal of Small Animal Practice
|August 26, 2003
PubMed
Summary

Long-term cabergoline treatment in dogs can cause transient coat color changes, particularly in fawn and Argentine boar hound breeds. This side effect is linked to the drug

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Area of Science:

  • Veterinary Pharmacology
  • Canine Dermatology
  • Endocrinology

Background:

  • Pseudopregnancy and estrus induction are common reproductive conditions in female dogs.
  • Dopaminergic agonists like cabergoline and bromocriptine are used for these conditions.
  • Potential side effects of these drugs require thorough investigation.

Purpose of the Study:

  • To investigate the occurrence and nature of coat color changes in dogs treated with cabergoline or bromocriptine.
  • To determine the relationship between treatment duration and the development of coat color alterations.
  • To elucidate the potential mechanism behind drug-induced hair coat changes.

Main Methods:

  • Oral administration of cabergoline (5 microg/kg) or bromocriptine (15 microg/kg) daily to 60 female dogs.

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  • Treatment duration ranged from 2 to 45 days for pseudopregnancy or estrus induction.
  • Observation and documentation of any changes in coat color throughout the study period.

    • Main Results:

    • Seven dogs receiving cabergoline for over 14 days exhibited coat color changes.
    • Fawn-colored dogs developed a yellowish hue, while Argentine boar hounds showed black spotting on extremities.
    • These color shifts were not observed in previous untreated estrous cycles.

    Conclusions:

    • Long-term administration (over two weeks) of the dopaminergic agonist cabergoline may induce transient coat color changes in specific dog breeds.
    • Inhibition of melanocyte-stimulating hormone secretion is a potential mechanism for these observed hair coat alterations.
    • Transient coat color changes should be considered a possible side effect during long-term dopaminergic agonist therapy in dogs.