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[Research into simultaneous spectrophotometric determination of components in cough syrup by principal component
Li-qing Zhang1, Xiao-hua Wu, Xi Tang
1Department of Biological and Chemistry Engineering, Zhejiang University of Science and Technology, Hangzhou 310012, China.
Abstract:
Principal component regression (PCR) method is used to analyse five components: acetaminophen, p-aminophenol, caffeine, chlorphenamine maleate and guaifenesin. The basic principle and the analytical step of the approach are described in detail. The computer program of LHG is based on VB language. The experimental result shows that the PCR method has no systematical error as compared to classical method. The experimental result shows that the average recovery of each component is all in the range from 96.43% to 107.14%. Each component obtains satisfactory result without any pre-separation. The approach is simple, rapid and suitable for the computer-aid analysis.