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Language function and dysfunction in corticobasal degeneration.

Naida L Graham1, Thomas Bak, Karalyn Patterson

  • 1University Neurology Unit, University of Cambridge, UK.

Neurology
|August 27, 2003
PubMed
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Phonologic impairment is a common feature of corticobasal degeneration (CBD), even in patients without obvious aphasia. This study highlights language difficulties as a key aspect of CBD progression.

Area of Science:

  • Neuroscience
  • Neurology
  • Linguistics

Background:

  • Corticobasal degeneration (CBD) is a rare neurodegenerative disorder.
  • Language functioning in CBD has not been systematically studied.
  • Aphasia is occasionally reported in CBD, but milder language deficits are less understood.

Observation:

  • Ten patients with CBD underwent comprehensive neuropsychological testing.
  • Assessments covered verbal fluency, naming, reading, spelling, memory, phonologic processing, visuospatial skills, and semantic memory.
  • Phonologic and spelling impairments were frequently observed, even in patients without overt aphasia.

Findings:

  • Phonologic impairment is a typical characteristic of corticobasal degeneration (CBD).
  • Deficits in phonologic processing and spelling were prevalent, irrespective of frank aphasia.

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  • Visuospatial, constructional, and frontal impairments were consistent with prior research.
  • Mild deficits in semantic memory, naming, and reading were noted in a subset of patients.

    • Implications:

    • Phonologic impairment is a core feature of CBD, extending beyond typical aphasia.
    • There is significant overlap between progressive nonfluent aphasia and CBD.
    • Linguistic deficits in CBD may represent a spectrum from mild phonologic impairment to severe aphasia.