Assessment of regional systolic and diastolic dysfunction in familial hypertrophic cardiomyopathy using MR tagging

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Magnetic Resonance Derived Myocardial Strain Assessment Using Feature Tracking
07:21

Magnetic Resonance Derived Myocardial Strain Assessment Using Feature Tracking

Published on: February 12, 2011

Daniel B Ennis1, Frederick H Epstein, Peter Kellman

  • 1Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. dennis@bme.jhu.edu

Magnetic Resonance in Medicine
|August 27, 2003
PubMed

Insights

Familial hypertrophic cardiomyopathy (FHC) impairs heart muscle function. This study found reduced systolic and diastolic function in FHC patients using advanced MRI techniques, highlighting regional differences in impairment.

Area of Science:

  • Cardiology
  • Medical Imaging
  • Biophysics

Background:

  • Familial hypertrophic cardiomyopathy (FHC) is characterized by left ventricular (LV) dysfunction.
  • Diastolic and systolic impairments significantly contribute to FHC symptoms.

Purpose of the Study:

  • To compare regional LV function (midwall circumferential strain) during systole and diastole in FHC patients versus normal volunteers.
  • To assess the utility of MR tagging with CSPAMM and CAPTOR for quantifying myocardial function throughout the cardiac cycle.

Main Methods:

  • Utilized prospectively-gated fast gradient-echo sequence with echo-train readout.
  • Modified sequence to support complementary spatial modulation of magnetization (CSPAMM) tagging.
  • Employed cardiac phase to order reconstruction (CAPTOR) for full cardiac cycle data acquisition and tag persistence.

Main Results:

  • FHC patients showed significantly reduced total systolic strains in septal and inferior regions (P < 0.01).
  • Early-diastolic strain rates were reduced in all regions of the FHC group (P < 0.03).
  • Demonstrated regional differences in systolic and diastolic impairment in FHC.

Conclusions:

  • The combination of CSPAMM and CAPTOR enables quantification of regional myocardial function throughout the cardiac cycle.
  • This technique effectively reveals regional systolic and diastolic impairments in familial hypertrophic cardiomyopathy.

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