Plasma exchange in France: Epidemiology 2001

Area of Science:

• Medical Science
• Clinical Trials
• Health Informatics

Background:

• The French therapeutic apheresis registry was established in 1985.
• It compiles data on indications, techniques, and complications of apheresis procedures.
• As of 2001, the registry contained data from over 16,700 patients and 153,641 sessions.

Purpose of the Study:

• To analyze trends in therapeutic apheresis indications, techniques, and complications in France.
• To evaluate the evolution of patient demographics and treatment modalities over time.
• To highlight the significance of the French registry as a global data resource.

Main Methods:

• Retrospective analysis of data collected by the French therapeutic apheresis registry.
• Categorization of indications into five major groups: neurology, hematology, nephrology, vasculitis, and endocrinology.
• Tracking of changes in plasma substitution fluids and vascular access methods.

Main Results:

• Neurology was the leading indication until 2000, but decreased due to high-dose IVIg use for specific conditions.
• Hematology emerged as the leading indication, driven by increased treatment for thrombotic thrombocytopenic purpura (TTP) and hemolytic uremic syndrome (HUS).
• Endocrinology (familial hypercholesterolemia) accounted for 10% of patients and 18.7% of sessions. Peripheral venous access remained most common. Immediate complications halved over 15 years.

Conclusions:

• The French therapeutic apheresis registry is the world's largest database for apheresis.
• Shifting trends in indications reflect changes in treatment protocols and disease prevalence.
• The registry facilitates numerous scientific studies and provides valuable insights into apheresis practices and outcomes.