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A synthetic approach to nomofungin/communesin B
Seth L Crawley1, Raymond L Funk
1Department of Chemistry, Pennsylvania State University, University Park, Pennsylvania 16802, USA.
Organic Letters
|August 29, 2003
Abstract:
[reaction: see text] A highly stereoselective intramolecular cycloaddition of an indole tethered to an aza-ortho-xylylene intermediate effects the rapid construction of a substantial portion of the ring system of the cytotoxic natural product communesin B. An analogous cycloaddition involving an ortho-quinone methide intermediate provides an adduct that clearly revealed that the structural assignment for nomofungin was in error.