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Direct Restart of a Replication Fork Stalled by a Head-On RNA Polymerase
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S-phase checkpoint proteins Tof1 and Mrc1 form a stable replication-pausing complex

Yuki Katou1, Yutaka Kanoh, Masashige Bando

  • 1Genome Structure and Function Team, Human Genome Research Group, RIKEN Genomic Science Center, 1-7-22 Suehiro-cho, Japan.

Nature
|August 29, 2003
PubMed
Summary

Checkpoint proteins Tof1 and Mrc1 directly interact with DNA replication machinery. This interaction creates a stable complex that pauses replication and anchors DNA repair during cell cycle S phase.

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