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Non-covalent stabilization of a beta-hairpin peptide into liposomes
Dennis W P M Löwik1, Jeffrey G Linhardt, P J Hans M Adams
1Department of Organic Chemistry University of Nijmegen, Toernooiveld 1-U177, 6525 ED Nijmegen, The Netherlands. lowik@sci.kun.nl
Organic & Biomolecular Chemistry
|August 30, 2003
Abstract:
An oligopeptide modified on both the N- and C-termini with hydrophobic moieties was prepared on a solid phase and anchored into a liposome, stabilizing the fold of the peptide into a beta-hairpin, which would otherwise be a random coil.