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Related Experiment Videos

Umbilical ascorbic acid levels in fetal distress.

M Dvir1, D Kohelet, E Arbel

  • 1Department of Neonatology, Assaf Harofeh Medical Center, Zerifin, Israel.

Journal of Nutritional Science and Vitaminology
|October 1, 1992
PubMed
Summary
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Infants experiencing intrapartum fetal distress show significantly higher umbilical cord ascorbic acid levels. This increase occurs even without observable clinical signs of distress at birth.

Area of Science:

  • Perinatal Medicine
  • Biochemistry
  • Neonatology

Background:

  • Ascorbic acid (vitamin C) plays a crucial role in fetal development and maternal health.
  • Investigating nutrient levels in umbilical cord blood provides insights into the intrauterine environment.
  • Fetal distress can impact various physiological parameters, including nutrient transfer.

Purpose of the Study:

  • To compare maternal and umbilical cord plasma ascorbic acid levels at birth.
  • To investigate the relationship between umbilical cord ascorbic acid levels and the presence of fetal distress.
  • To assess the predictive value of umbilical cord ascorbic acid for fetal distress.

Main Methods:

  • Collection of maternal arterial and umbilical cord arterial/venous blood samples immediately after birth.

Related Experiment Videos

  • Analysis of umbilical cord venous blood for plasma ascorbic acid concentrations.
  • Analysis of maternal arterial blood for plasma ascorbic acid concentrations.
  • Comparison of ascorbic acid levels between mothers and infants, and between infants with and without fetal distress.

    • Main Results:

    • Umbilical cord plasma ascorbic acid levels were significantly higher than maternal levels (172.9 vs. 57.8 mumol/liter).
    • No significant correlation was found between maternal and umbilical cord ascorbic acid levels.
    • Infants with fetal distress exhibited significantly higher umbilical cord ascorbic acid levels (191.9 vs. 157.4 mumol/liter).
    • An umbilical cord ascorbic acid cut-off of 95.8 mumol/liter predicted fetal distress with 76% sensitivity and 67% specificity.

    Conclusions:

    • Intrapartum fetal distress is associated with a substantial increase in fetal ascorbic acid levels.
    • Elevated umbilical cord ascorbic acid may serve as a biomarker for intrapartum fetal distress, even in the absence of overt clinical signs.
    • Further research is warranted to understand the mechanisms behind this ascorbic acid elevation in fetal distress.