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Related Experiment Videos

Quantification of urinary iodine: a need for revised thresholds.

C Als1, C Minder, D Willems

  • 1Institute of Pathology, Inselspital, University of Bern, Bern, Switzerland.

European Journal of Clinical Nutrition
|August 30, 2003
PubMed
Summary

Urinary iodine concentration (I/L) and iodine-to-creatinine ratio (I/creatinine) underestimate iodine intake compared to iodine excretion (I/24h). Separate reference ranges are needed for accurate iodine status assessment.

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Clinical biochemistry·2018

Area of Science:

  • Biochemistry
  • Nutritional Science
  • Public Health

Background:

  • Accurate assessment of iodine intake is crucial for public health.
  • Urinary iodine concentration (I/L) and iodine-to-creatinine ratio (I/creatinine) are commonly used in field studies.
  • Comparability of these measures with 24-hour urinary iodine excretion (I/24h) is often assumed but debated.

Purpose of the Study:

  • To compare different methods of reporting urinary iodine levels.
  • To assess the comparability of I/L, I/creatinine, and I/24h for iodine supply estimation.
  • To determine if current reporting methods accurately reflect iodine intake.

Main Methods:

  • Comparison of I/24h, I/L, and I/creatinine in precise 24-hour urine collections.
  • Analysis of I/L and I/creatinine in spot urine samples.

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  • Inclusion of 13 subjects across two locations (Bern and Brussels) with 110 total 24-hour collections.

    • Main Results:

    • Iodine intake was mildly deficient in both study locations based on WHO criteria.
    • I/creatinine and I/L systematically underestimated iodine intake compared to I/24h (P<0.0002).
    • Significant discrepancies were observed, with I/creatinine and I/L classifying more samples as deficient than I/24h.

    Conclusions:

    • I/creatinine and I/L significantly underestimate iodine intake when compared to I/24h.
    • Urgent need to establish distinct reference ranges for I/24h, I/creatinine, and I/L.
    • Deviations may be even more pronounced in larger population studies, impacting iodine status assessment.