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The ASICs: signaling molecules? Modulators?

Oleg Krishtal¹

¹Bogomoletz Institute of Physiology, Bogomoletz Str. 4, 01024, Kiev, Ukraine. krishtal@serv.biph.kiev.ua

Trends in Neurosciences

|September 2, 2003

Summary

Acid-sensing ionic channels (ASICs) are vital for sensory perception and cognitive functions like learning and memory. Further research is needed to understand how pH fluctuations activate these channels for their physiological roles.

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Area of Science:

Neuroscience
Physiology

Background:

Acid-sensing ionic channels (ASICs) are widely distributed throughout the mammalian nervous system.
Recent knockout studies provide strong evidence for their physiological importance.

Purpose of the Study:

To summarize the known functions of ASICs in sensory modalities and cognitive processes.
To highlight the unresolved questions regarding ASIC activation mechanisms and physiological relevance.

Main Methods:

Review of recent knockout experiments.
Analysis of existing literature on ASIC function.

Main Results:

ASICs play key roles in mechanoreception and nociception at the periphery.
ASICs are implicated in learning and memory functions within the brain.

Conclusions:

The precise mechanisms by which ASICs mediate their functions are not fully understood.
Determining if physiological pH fluctuations are sufficient to activate ASICs is critical for understanding their functional significance.

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