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Cardiovascular autonomic dysfunction in primary Sjögren's syndrome.
László Kovács1, Dóra Paprika, Róbert Tákacs
1Department of Rheumatology, Faculty of Medicine, University of Szeged, Szeged, Hungary. kovl@in1st.szote.u-szeged.hu
Rheumatology (Oxford, England)
|September 2, 2003
Summary
Cardiovascular autonomic nervous system dysfunction is common in primary Sjögren
Area of Science:
- Rheumatology
- Neurology
- Cardiology
Background:
- Primary Sjögren's syndrome (pSS) is a systemic autoimmune disease.
- Autonomic dysfunction can affect various organ systems in pSS.
Purpose of the Study:
- To evaluate the prevalence and clinical importance of cardiovascular autonomic nervous system (CANS) dysfunction in patients with pSS.
Main Methods:
- A case-control study involving 51 pSS patients and healthy controls.
- Utilized heart rate and blood pressure variability, baroreflex sensitivity, and cardiovascular reflex tests.
Main Results:
- pSS patients exhibited significantly lower heart rate and blood pressure variability and baroreflex sensitivity compared to controls.
- Abnormal results in cardiovascular reflex tests and elevated autonomic neuropathy scores were more frequent in pSS patients.
Conclusions:
- The majority of primary Sjögren's syndrome patients demonstrate signs of cardiovascular autonomic nervous system dysfunction.
- This dysfunction appears to be a significant clinical feature in pSS.