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Cardiovascular hemodynamics: relationships with insulin resistance in obese children

U Giordano1, P Ciampalini, A Turchetta

  • 1Sports Medicine Unit, Pediatrics Department, Bambino Gesù Children's Hospital, Research Institute, Piazza S. Onofrio, 4, 00165 Rome, Italy. giordano@opbg.net

Pediatric Cardiology
|September 2, 2003
PubMed

Insights

Obese children show reduced exercise tolerance and higher blood pressure, linked to insulin resistance and left ventricular mass. Regular screening is recommended to prevent early cardiovascular damage in this group.

Area of Science:

  • Pediatric Endocrinology
  • Cardiovascular Physiology
  • Metabolic Health

Background:

  • Obesity in children is a growing concern with potential long-term cardiovascular implications.
  • Understanding the interplay between metabolic and cardiovascular parameters in obese children is crucial for early intervention.

Purpose of the Study:

  • To investigate the relationships between blood pressure, cardiac output, systemic vascular resistance, and metabolic markers (insulin, glucose) in obese children.
  • To compare cardiovascular parameters in obese children with healthy controls.
  • To explore correlations between cardiovascular and metabolic factors, including insulin sensitivity and left ventricular mass.

Main Methods:

  • Comparison of cardiovascular parameters (BP, CO, SVR) at rest and during exercise (Bruce Protocol) between obese children and healthy controls.
  • Assessment of insulin sensitivity index (ISI) via oral glucose tolerance test and left ventricular mass (LVM) via echocardiography in obese children.
  • Statistical analysis including Student's t-test and linear regression to identify significant relationships.

Main Results:

  • Obese children exhibited significantly reduced time of exercise (TE) and elevated blood pressure compared to controls.
  • Linear regression analysis revealed significant correlations between blood pressure, insulin sensitivity index (ISI), and left ventricular mass (LVM).

Conclusions:

  • Obese children demonstrate impaired cardiovascular function and altered metabolic profiles.
  • The findings suggest a need for regular cardiovascular and metabolic screening in obese children to mitigate the risk of early cardiovascular damage.

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