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Comparison of two advanced hybrid closed loop in a pediatric population with type 1 diabetes: a real-life

R Schiaffini1, A Deodati2, M C Nicoletti3

  • 1Diabetes Unit, Bambino Gesù Children's Hospital, Piazza S Onofrio, 4, 00165, Rome, Italy. riccardo.schiaffini@opbg.net.

Acta Diabetologica
|April 22, 2022
PubMed

Insights

Upgrading to Advanced Hybrid Closed Loop (AHCL) systems significantly improved glucose control in children with Type 1 Diabetes. Both Medtronic 780G and Tandem Control IQ systems demonstrated comparable effectiveness in real-world use.

Area of Science:

  • Pediatric Endocrinology
  • Biomedical Engineering
  • Diabetes Technology

Background:

  • Advanced Hybrid Closed Loop (AHCL) systems offer potential improvements in glucose management for children with Type 1 Diabetes (T1D).
  • Real-world clinical data is crucial for evaluating the efficacy of these advanced diabetes technologies.

Purpose of the Study:

  • To compare the metabolic control achieved by two specific AHCL systems: the Medtronic 780G and the Tandem Control IQ.
  • To assess the effectiveness of these systems in a pediatric population with T1D in a real-life clinical setting.

Main Methods:

  • An observational, real-life, monocentric study involving 31 children and adolescents with T1D.
  • Continuous Glucose Monitoring (CGM) data from the four weeks prior to AHCL use (PRE period) were compared with the first four weeks of AHCL use (POST period).
  • Participants had previously used Predictive Low Glucose Suspend (PLGS) systems before upgrading to AHCL.

Main Results:

  • Both AHCL systems led to a significant increase in Time in Range (TIR) within four weeks of use.
  • Medtronic 780G system showed an increase in TIR from 65.7% to 70.5% (p < 0.01).
  • Tandem Control IQ system showed an increase in TIR from 64.8% to 70.1% (p < 0.01).
  • No significant differences were observed between the two AHCL systems in analyzed CGM metrics post-upgrade.

Conclusions:

  • This study represents the first real-world comparison of two AHCL systems in pediatric T1D patients.
  • Upgrading to AHCL systems demonstrates an overall improvement in glucose control.
  • The Medtronic 780G and Tandem Control IQ systems exhibit comparable efficacy in enhancing glucose control for pediatric T1D management.
Abstract

Keywords:
Advanced Hybrid Closed LoopDiabetesPediatricType 1 diabetes

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