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Epidermal basaloid proliferation in cutaneous myxomas.
Darius R Mehregan1, Laura Thomas, Jean E Thomas
1Pinkus Dermatopathology Laboratory, P.C., Monroe, MI 48161, USA.
Journal of Cutaneous Pathology
|September 3, 2003
Summary
Basaloid proliferations overlying cutaneous myxomas are benign adnexal growths, not superficial basal cell carcinoma. These findings suggest they are similar to those seen over dermatofibromas.
Area of Science:
- Dermatopathology
- Oncology
Background:
- Basaloid epidermal proliferations can mimic basal cell carcinoma.
- Cutaneous myxomas are benign mesenchymal tumors.
Purpose of the Study:
- To differentiate basaloid proliferations overlying cutaneous myxomas from basal cell carcinoma.
- To investigate the nature of these basaloid proliferations.
Main Methods:
- Histological examination of 30 cutaneous myxomas.
- Immunohistochemical staining for epidermal growth factor receptor (EGF-r) and p53 protein.
- Alcian blue staining to assess myxoid changes.
Main Results:
- Nine of 30 myxomas showed overlying basaloid proliferation.
- Proliferations were epidermal, overlying dermal myxoid changes.
- Rare mitotic figures and scattered p53 staining were observed.
- EGF-r staining was positive in five cases.
Conclusions:
- Basaloid proliferations overlying cutaneous myxomas are likely benign adnexal proliferations.
- These are analogous to basaloid proliferations seen over dermatofibromas.
- They do not represent superficial basal cell carcinoma.