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A PRKCA-Fused Blue Melanocytoma Expressing a Truncated ALK Isoform
Hadrien Reboul1, Isabelle Thibaut2, Philippe Galinier3
1Pathology Department, University Hospital Center, IUCT-University Cancer Institute, Toulouse, France.
Journal of Cutaneous Pathology
|July 10, 2026
Summary
This study reports the first case of a PRKCA-fused blue melanocytoma in a young girl, identified as ALK-positive due to alternative transcription initiation (ATI). This finding expands the understanding of melanocytic tumor genetics.
Area of Science:
- Oncology
- Dermatopathology
- Molecular Genetics
Background:
- Melanocytic tumors are classified by the WHO based on genetic profiles.
- Blue nevi and Spitz tumors are distinct categories within melanocytic neoplasms.
- Genetic alterations are key to understanding melanocytic tumor behavior.
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