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Design and parallel synthesis of piperidine libraries targeting the nociceptin (N/OFQ) receptor
Zhengming Chen1, Wendy S Miller, Shen Shan
1Computational, Combinatorial and Medicinal Chemistry, Purdue Pharma L.P., 6 Cedar Brook Drive, Cranbury, NJ 08512, USA. zhengming.chen@pharma.com
Bioorganic & Medicinal Chemistry Letters
|September 3, 2003
Abstract:
Based on literature structures, we proposed a pharmacophore for NOP receptor ligands and used it as a guide for the design of a focused piperidine library and an optimization library. Potent NOP receptor agonists and antagonists were obtained from these libraries as well as a few potent, mu selective agonists.