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Related Experiment Videos

[The tail suspension test: its theory and practical application].

S Nomura1, R Naruse, H Okada

  • 1Department of Neuropsychiatry, Tachikawa Hospital, Japan.

Yakubutsu, Seishin, Kodo = Japanese Journal of Psychopharmacology
|October 1, 1992
PubMed
Summary
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The tail suspension test (TST) assesses antidepressant effects by measuring immobility in mice. Repeated antidepressant administration, unlike single doses, reversed this immobility in a newly developed automated device.

Area of Science:

  • Neuroscience
  • Pharmacology
  • Behavioral Science

Context:

  • The tail suspension test (TST) is a standard method for screening antidepressant drugs.
  • Previous research indicated that tail suspension-induced immobility in mice is antagonized by antidepressants.
  • An automated version, ITEMATIC-TST, was previously developed.

Purpose:

  • To describe a novel, automated device for the tail suspension test.
  • To evaluate the efficacy of antidepressants using the new device.
  • To compare the findings with the original TST.

Summary:

  • A new automated tail suspension test (TST) apparatus was developed using a spring, potentiometer, A/D converter, and PC.
  • Results showed that repeated administration of tricyclic and atypical antidepressants reversed immobility in mice.

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  • Methamphetamine also activated behavior, but other psychotropic drugs did not yield positive results.

    • Impact:

    • The developed device offers a new tool for behavioral pharmacology research.
    • Findings suggest repeated antidepressant administration is key for reversing TST immobility.
    • The study discusses the utility and limitations of the new device compared to the original TST.