Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hypertension: beta testing.

Michael Kotlikoff1, Ian Hall

  • 1Department of Biomedical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853-6401, USA. mik7@cornell.edu

The Journal of Clinical Investigation
|September 4, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Digitization of Historical Data from Somalia's Last Smallpox Outbreaks 1976-1977.

Scientific data·2026
Same author

"The best way we can stop suicides is by making lives worth living": a mixed-methods survey in the UK of perspectives on suicide prevention from the autism community.

EClinicalMedicine·2026
Same author

Correction: The Burr distribution as a model for the delay between key events in an individual's infection history.

PLoS computational biology·2026
Same author

Misinformation harms medicine.

Lancet (London, England)·2026
Same author

Study protocol for the Champaign-Urbana population study.

Frontiers in neuroimaging·2026
Same author

Professor Ian Hall's contribution to the Discussion of 'Some statistical aspects of the COVID-19 response' by Wood et al.

Journal of the Royal Statistical Society. Series A, (Statistics in Society)·2026
Same journal

Pharmacokinetics and pharmacodynamics of a long-acting monoclonal antibody against malaria in African adults.

The Journal of clinical investigation·2026
Same journal

Extracellular matrix reprogramming by the YAP/TAZ- TGF-ß2 axis drives immune exclusion in cholangiocarcinoma models.

The Journal of clinical investigation·2026
Same journal

Tumor cell-derived extracellular vesicles foster the immunosuppressive landscape of pancreatic cancer.

The Journal of clinical investigation·2026
Same journal

Julie Zikherman receives the ASCI/Marian W. Ropes, MD, Award.

The Journal of clinical investigation·2026
Same journal

Targeted degradation of MDM2 overcomes feedback regulation of p53 signaling in Merkel cell carcinoma models.

The Journal of clinical investigation·2026
Same journal

SGLT2 inhibitors enhance ketogenesis by acting as allosteric activators of the mitochondrial enzyme HMGCS2.

The Journal of clinical investigation·2026
See all related articles

Angiotensin-induced hypertension significantly reduces BK channel beta subunit expression. This finding suggests the beta subunit plays a crucial role in regulating blood vessel tone.

Area of Science:

  • Cardiovascular Physiology
  • Molecular Biology
  • Ion Channel Function

Background:

  • Hypertension is a major cardiovascular risk factor.
  • The BK channel regulates vascular smooth muscle relaxation.
  • The role of BK channel subunits in hypertension is not fully understood.

Discussion:

  • Angiotensin II infusion in a rat model led to decreased expression of the BK channel beta subunit.
  • This downregulation was observed in the aorta, a major blood vessel.
  • The findings implicate the BK channel beta subunit in the pathophysiology of hypertension.

Key Insights:

  • A significant reduction in BK channel beta subunit expression occurs during angiotensin-induced hypertension.
  • This suggests the beta subunit is a key player in the vascular response to hypertensive stimuli.

Related Experiment Videos

  • The study provides novel insights into the molecular mechanisms underlying hypertension.

    • Outlook:

    • Further research is needed to elucidate the precise mechanisms by which the beta subunit regulates vascular tone.
    • Targeting the BK channel beta subunit could offer new therapeutic strategies for hypertension.
    • Investigating the upstream regulators of beta subunit expression is a promising future direction.