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Systematic characterization of oil-in-water emulsions for formulation design
1Laboratoire de Technologie Pharmaceutique, Département de Pharmacie, Université de Liège, Bât. B36, Tour 4, Avenue de l'Hôpital, 1, Liège B 4000, Belgium. iroland@ulg.ac.be
Abstract:
Oil-in-water emulsions varying in surfactant concentration and manufacturing process were prepared. About 10 experiments were performed to characterize them. The goal of this research was to find out which tests should systematically be carried out to assess efficiently the stability and the properties of an emulsified preparation. Thus, formulation design requires at least the measurement of the droplet size, the determination of the zeta potential, a TurbiScan analysis, the investigation of the stability under centrifugation and freeze/thaw cycles. If the emulsion contains an active substance, stability under storage at 4 degrees C and microscopic analysis are relevant. Quality control should be improved by measurements of viscosity and pH.