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Updated: Sep 9, 2026

The WATCHMAN Left Atrial Appendage Closure Device for Atrial Fibrillation
Published on: February 28, 2012
Atrial fibrillation induced by simvastatin treatment in a 61-year-old man
Takemi Akahane1, Katsufumi Mizushige, Hatsumi Nishio
1Third Department of Internal Medicine, Nara Medical University, Nara, Japan.
Abstract:
A 61-year-old man developed atrial fibrillation 2 weeks after the administration of simvastatin (5 mg once daily) and recovered to sinus rhythm 3 days after withdrawal of the drug. Electrocardiography had not previously revealed an abnormality except for transient atrial fibrillation and left atrial overloading. Although he has not been given any antiarrhythmic agents, sinus rhythm is being continuously maintained. The timing of the transient atrial fibrillation attack was closely related to the administration of simvastatin. An inhibitory effect of myocardial energy metabolism through ubiquinone synthesis may play a role in the development of atrial fibrillation.
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