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Fully automated multi-step solution phase synthesis using polymer supported reagents: preparation of histone
Emma Vickerstaffe1, Brian H Warrington, Mark Ladlow
1GlaxoSmithKline Cambridge Technology Centre, University of Cambridge, Lensfield Road, Cambridge, UK CB2 1EW.
Organic & Biomolecular Chemistry
|September 6, 2003
Abstract:
The first fully automated multi-step polymer assisted solution phase (PASP) synthesis is described. An array of histone deacetylase (HDAc) inhibitors was prepared by an unattended 4-5 step sequence incorporating in-line 'catch and release' purification.