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Intravascular papillary endothelial hyperplasia arising from the upper lip
Kenichi Matsuzaka1, Yoshihiko Koike, Takashi Yakushiji
1Department of Clinical Pathophysiology, Oral Health Science Center, Tokyo Dental College, 1-2-2 Masago, Mihama-ku, Chiba 261-8502, Japan. matsuzak@tdc.ac.jp
The Bulletin of Tokyo Dental College
|September 6, 2003
Summary
We describe a rare instance of intravascular papillary endothelial hyperplasia (IPEH) in the upper lip. This benign vascular tumor exhibited high proliferative activity, confirmed by immunohistochemical markers.
Area of Science:
- Pathology
- Oncology
- Dermatology
Background:
- Intravascular papillary endothelial hyperplasia (IPEH) is a rare, benign vascular lesion.
- IPEH can occur in various locations, but upper lip involvement is uncommon.
Observation:
- A case of IPEH originating from the upper lip is presented.
- Pathological examination revealed lobulated masses with papillary structures and an incomplete fibrous capsule.
Findings:
- The lesion showed poorly defined capillary formation and frequent mitotic figures.
- Immunohistochemistry confirmed endothelial cell proliferation, with positive staining for factor VIII related antigen, vimentin, and PCNA.
Implications:
- This case highlights the importance of considering IPEH in the differential diagnosis of upper lip masses.
- The high proliferative activity noted suggests careful monitoring may be warranted.