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Episodic memory in schizophrenic patients and their relatives.

T Toulopoulou1, S Rabe-Hesketh, H King

  • 1Division of Psychological Medicine [Box 63], Institute of Psychiatry, De Crespigny Park, , London SE5 8AF, UK. t.toulopoulou@iop.kcl.ac.uk

Schizophrenia Research
|September 6, 2003
PubMed
Summary

Genetic liability to schizophrenia may manifest as verbal memory deficits in relatives. This study found significant verbal memory impairment in healthy relatives of schizophrenia patients, suggesting a shared genetic basis for cognitive dysfunction.

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Genetics

Background:

  • Schizophrenia is associated with cognitive impairments.
  • Healthy relatives of schizophrenia patients exhibit memory dysfunction, suggesting a genetic link.

Purpose of the Study:

  • To investigate the nature of memory dysfunction transmitted in families with schizophrenia.
  • To determine if cognitive deficits are present in healthy relatives of schizophrenia patients.

Main Methods:

  • Assessed memory function in 62 schizophrenia patients, 98 healthy relatives, and 66 controls.
  • Utilized Wechsler Memory Scale (WMS) subtests for immediate/delayed recall, retention, and learning (verbal and visual).
  • Assessed general intellectual function using the Wechsler Adult Intelligence Scale-Revised (WAIS-R).

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Main Results:

  • Schizophrenia patients showed significant memory deficits compared to controls.
  • Relatives exhibited deficits in verbal memory (Logical Memory) and visual learning (Abstract Paired Associates).
  • Verbal memory impairment was more pronounced than other deficits and persisted even after excluding certain diagnoses.

Conclusions:

  • Familial liability to schizophrenia may be expressed as verbal memory dysfunction.
  • Cognitive impairment in relatives suggests a shared genetic influence on schizophrenia and memory deficits.