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No evidence of association between HLA-DRB1 and attention deficit hyperactivity disorder
Antony Payton1, Darko Turic, Kate Langley
1Centre for Integrated Genomic Medical Research, Stopford Building, Manchester University, Manchester, UK.
Objectives:
There has been a recent resurgence in interest in the role of autoimmunity in childhood neuropsychiatric disorders. Significant association between HLA-DRB1 and attention deficit hyperactivity disorder (ADHD) in a case-control study of 31 subjects has been reported but there have been no other published studies following up these results. We attempted to replicate these findings.
Methods:
In a well-characterized sample of 173 children with ADHD, using a fully automated sequence-specific oligonucleotide method for HLA genotyping, association between ADHD and HLA-DRB1 was tested for using the Transmission Disequilibrium Test and case-control analysis.
Results:
Transmission Disequilibrium Test analysis yielded a chi-square of 10.694 with a simulated global P value of 0.1641 for the full sample, and a chi-square value of 11.307 with a simulated global P value of 0.1323 for the complete trios only.
Conclusion:
There was no evidence of association of HLA-DRB1 and ADHD.