Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Clinical pathology testing regulatory concerns.

J Kanno1

  • 1Department of Pathology, Faculty of Medicine, Tokyo Medical and Dental University, Japan.

Toxicologic Pathology
|January 1, 1992
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The association between the T309G polymorphism of the MDM2 gene and sensitivity to anticancer drug is dependent on the p53 mutational status in cellular models.

British journal of cancer·2009
Same author

Identification of genes that restrict astrocyte differentiation of midgestational neural precursor cells.

Neuroscience·2008
Same author

PTOV1: a novel testosterone-induced atherogenic gene in human aorta.

The Journal of pathology·2006
Same author

The OECD program to validate the rat uterotrophic bioassay to screen compounds for in vivo estrogenic responses: phase 1.

Environmental health perspectives·2001
Same author

Transgene expression of thioredoxin (TRX/ADF) protects against 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced hematotoxicity.

Archives of environmental contamination and toxicology·2001
Same author

Hemopoietic cell kinetics after intraperitoneal single injection of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in mice.

Chemosphere·2001
Same journal

New Approach Methodologies (NAMs) for Carcinogenicity Evaluation.

Toxicologic pathology·2026
Same journal

2025 International Academy of Toxicologic Pathology (IATP) Satellite Symposium: Pathology Working Groups (PWGs) in Toxicologic Pathology.

Toxicologic pathology·2026
Same journal

Toxicologic Pathology Forum*: Opportunities and Challenges in the Use of Artificial Intelligence in Nonclinical Toxicologic Histopathology Evaluations.

Toxicologic pathology·2026
Same journal

New Modalities and Carcinogenicity Assessment.

Toxicologic pathology·2026
Same journal

Second Joint Annual Congress of the British Society of Toxicologic Pathology and the European Society of Toxicologic Pathology Special Issue.

Toxicologic pathology·2026
Same journal

Hemangiosarcomas in Intercostal Brown Adipose Tissues of the Sternum Induced by Urethane in TgrasH2 Mice.

Toxicologic pathology·2026
See all related articles

Animal toxicity testing faces challenges with unknown endpoints and multiple data sets. New interpretation methods are needed to avoid false positives and improve data analysis for human health risk assessment.

Area of Science:

  • Toxicology
  • Veterinary Pathology
  • Biostatistics

Background:

  • Animal models are crucial surrogates for human toxicity testing.
  • Current animal toxicity testing relies heavily on clinical and anatomical pathology.
  • Significant differences exist between human diagnosis and animal toxicity testing protocols.

Purpose of the Study:

  • To address practical challenges in clinical pathology testing for toxicity.
  • To propose methods for preselecting test items with unknown toxicity endpoints.
  • To develop strategies for handling multiple data sets in toxicity detection.

Main Methods:

  • Discussion of "significantosis" as a "disease" concept.
  • Introduction of integrated interpretation for biologically related items.

Related Experiment Videos

  • Exploration of case-by-case data interpretation procedures.

    • Main Results:

    • Identified issues of false-positive rate inflation and multicomparison problems.
    • Proposed methods to avoid false-positive judgments and outlier data censoring.
    • Highlighted the exploratory nature of toxicity tests with unknown, multiple endpoints.

    Conclusions:

    • Toxicity test interpretation requires a case-by-case approach due to exploratory nature and unknown endpoints.
    • Integrated interpretation of related biological data can mitigate false positives.
    • Development of toxicity entity-oriented databases is recommended for improved interpretation.