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[Salmonellosis: therapeutic aspects].

D Guillemot1, C Carbon

  • 1Service de médecine interne, CHU Bichat, Paris.

La Revue Du Praticien
|November 15, 1992
PubMed
Summary

Antibiotic resistance in salmonellosis has shifted treatment strategies. Fluoroquinolones show efficacy but carry risks of resistance and persistent carriage, requiring careful consideration in Salmonella infections.

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Area of Science:

  • Microbiology
  • Infectious Diseases
  • Pharmacology

Context:

  • Antibiotic therapy for salmonellosis has evolved over the past decade.
  • Increasing resistance to traditional antibiotics necessitates new treatment approaches.
  • Enhanced understanding of antimicrobial efficacy guides the use of novel compounds.

Purpose:

  • To evaluate the efficacy and tolerance of fluoroquinolones in treating Salmonella infections.
  • To assess the role of fluoroquinolones in managing acute diarrhea, chronic carriage, and typhoid fever.
  • To identify potential adverse outcomes associated with fluoroquinolone use.

Summary:

  • Fluoroquinolones have demonstrated significant efficacy in treating Salmonella infections, including typhoid fever and acute diarrhea.
  • These antibiotics can substantially reduce treatment duration compared to older therapies.
  • However, their use is associated with two critical concerns: the selection of resistant bacterial mutants and an increased risk of persistent Salmonella carriage.

Impact:

  • Fluoroquinolones represent a valuable therapeutic option for salmonellosis, offering improved treatment outcomes.
  • The emergence of fluoroquinolone resistance in Salmonella strains is a growing public health concern.
  • Careful monitoring and judicious use of fluoroquinolones are essential to mitigate the risks of resistance and persistent carriage.

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