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Inhibitory effects of Xanthii fructus extract on mast cell-mediated allergic reaction in murine model
Seung-Heon Hong1, Hyun-Ja Jeong, Hyung-Min Kim
1Department of Oriental Pharmacy, College of Pharmacy, VCRC of Wonkwang University, Iksan, Jeonbuk 570-749, South Korea.
Abstract:
The effect of aqueous extract of Xanthii fructus (XF) on mast cell-mediated allergic reaction has been investigated. XF inhibited compound 48/80-induced systemic anaphylaxis in mouse. This dose-dependently inhibited histamine release from rat peritoneal mast cells (RPMC) by compound 48/80. Additionally, XF inhibited local immunoglobulin E (IgE)-mediated passive cutaneous anaphylatic reaction. When XF (0.1mg/ml) was added, the secretion of tumor necrosis factor-alpha (TNF-alpha) from anti-dinitrophenyl (DNP) IgE antibody-stimulated mast cells was inhibited by 56%. Our studies provide evidence that XF may be beneficial in the treatment of various types allergic diseases.
