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Updated: Sep 20, 2026

Left Atrial Ligation in the Avian Embryo as a Model for Altered Hemodynamic Loading During Early Vascular Development
Published on: June 16, 2023
Abstract:
Sixteen years ago, hypoplastic left heart syndrome (HLHS) was a fatal diagnosis. Following birth and closing of the ductus arteriosus, HLHS infants developed metabolic acidosis, decreased systemic perfusion, circulatory collapse, and death. Currently, HLHS can be detected in fetuses in the first trimester of pregnancy. Today's families may choose from four HLHS treatment options, which include (a) medical termination of pregnancy (MTP), (b) supportive care, (c) Norwood (3 Staged) surgical procedure, and/or (d) cardiac transplantation. Presently, pharmacologic therapy with prostaglandin E1 stabilizes HLHS infants until the initiation of a treatment modality. As with many new treatment technologies, the availability of four options forces parents to make difficult decisions. Therefore, parents of HLHS infants require ongoing emotional support, information, and continual family teaching. Nurses caring for these critically ill infants must possess specific skills and knowledge.
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