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Antithrombin III (AT3) polymorphism in the marsupial Monodelphis domestica: identification and genetics
K Bell1, H Arthur, R A van Oorschot
1Department of Physiology and Pharmacology, University of Queensland, St. Lucia, Australia.
Biochemical Genetics
|December 1, 1992
Abstract:
Antithrombin III polymorphism was observed in the gray short-tailed opossum, Monodelphis domestica, by either one-dimensional polyacrylamide gel electrophoresis (PAGE; pH 7.9), two-dimensional PAGE (agarose, pH 5.4; 12% T, pH 7.9), or isoelectric focusing (pH 4.2-4.9) followed by immunoblotting with rabbit antiserum to human antithrombin III. Family studies demonstrated an inheritance of three codominant autosomal alleles, AT3A, AT3B, and AT3C, and a population study revealed frequencies of 0.70, 0.10, and 0.20, respectively.