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Radiation therapy for angiosarcoma.

Jon R Ward1, Steven J Feigenberg, Nancy Price Mendenhall

  • 1Department of Radiation Oncology, University of Florida Health Science Center, 2000 SW Archer Rd., Gainesville, Florida 32608, USA.

Head & Neck
|September 11, 2003
PubMed
Summary
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Radiation therapy for angiosarcoma shows a 5-year survival of 51%. Scalp angiosarcomas have a poor prognosis, with local recurrence being common. Aggressive treatment including surgery and radiation is recommended.

Area of Science:

  • Oncology
  • Radiation Oncology
  • Surgical Oncology

Background:

  • Retrospective analysis of 19 patients with angiosarcoma treated with curative intent radiation therapy between 1964 and 1998.
  • Focus on treatment outcomes and prognostic factors for angiosarcoma.

Purpose of the Study:

  • To evaluate the efficacy of radiation therapy in treating angiosarcoma.
  • To identify predictors of local control and survival.
  • To determine optimal treatment strategies for angiosarcoma, particularly scalp tumors.

Main Methods:

  • Review of patient records for 19 angiosarcoma cases treated with radiation therapy.
  • Median follow-up duration of 37 months.
  • Analysis of survival rates, local control, and patterns of recurrence.

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Main Results:

  • Actuarial 5-year absolute survival and local control rates were 51% and 50%, respectively.
  • Local recurrence was the predominant pattern of failure, especially for scalp angiosarcomas.
  • Tumor location was the sole significant predictor of local control and 5-year survival.

Conclusions:

  • Scalp angiosarcomas carry a dismal prognosis with a high rate of local recurrence.
  • Aggressive multimodal treatment, including surgical resection with adjuvant or neoadjuvant radiation therapy, is crucial.
  • Further research into optimizing treatment for angiosarcoma, especially in challenging locations, is warranted.