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Hawthorn extracts inhibit LDL oxidation

C Quettier-Deleu1, G Voiselle, J C Fruchart

  • 1Laboratoire de Pharmacognosie, Faculté de Pharmacie, Institut Pasteur, Lille, France.

Die Pharmazie
|September 12, 2003
PubMed

Insights

Hawthorn extracts, rich in polyphenols, effectively inhibit low-density lipoprotein (LDL) oxidation. This suggests hawthorn

Area of Science:

  • Cardiovascular Science
  • Phytochemistry
  • Biochemistry

Background:

  • Dietary polyphenols reduce cardiovascular risk by inhibiting LDL oxidation, a key event in atherosclerosis.
  • Hawthorn (Crataegus) is a polyphenol-rich plant used for heart conditions, known for antioxidant properties.

Purpose of the Study:

  • To evaluate the LDL oxidation inhibitory capacity of hawthorn extracts.
  • To correlate this activity with polyphenol content.

Main Methods:

  • Tested total and ethyl-acetate extracts from dried hawthorn (flowers, tops, fruits) for inhibition of copper-induced LDL oxidation.
  • Quantified total polyphenols, proanthocyanidins, dimeric procyanidin B2, and hyperoside.

Main Results:

  • Hawthorn extracts inhibited Cu(2+)-induced LDL oxidation.
  • Inhibitory capacity correlated positively with total polyphenols, proanthocyanidins, procyanidin B2, and hyperoside content.
  • Flavanol-type phenolics were particularly effective inhibitors.

Conclusions:

  • Hawthorn extracts possess significant LDL oxidation inhibitory properties.
  • These properties are attributed to their rich polyphenol content, especially flavanols.
  • Hawthorn is a potential natural source for compounds that combat atherosclerosis.

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