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Hyperpolarization-activated current (Ih) in the inferior colliculus: distribution and contribution to temporal

Ursula Koch1, Benedikt Grothe

  • 1Max-Planck Institute of Neurobiology, 82152 Martinsried, Germany. ukoch@neuro.mpg.de

Journal of Neurophysiology
|September 12, 2003
PubMed
Summary

The hyperpolarization-activated current (Ih) in inferior colliculus (IC) neurons enhances temporal processing. Ih improves precise temporal analysis in onset and adapting neurons, crucial for auditory processing.

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Area of Science:

  • Neuroscience
  • Auditory Neuroscience
  • Cellular Electrophysiology

Background:

  • The inferior colliculus (IC) is a key auditory center, but the role of ion currents like Ih in its neurons is poorly understood.
  • The hyperpolarization-activated current (Ih) is known to contribute to temporal information processing in the auditory brainstem.

Purpose of the Study:

  • To investigate the distribution and properties of the Ih current in IC neurons.
  • To determine Ih's contribution to neuronal excitability, synaptic integration, and temporal processing in the IC.

Main Methods:

  • Whole-cell current- and voltage-clamp recordings were performed on IC neurons in acute rat brain slices.
  • Neuronal response types were classified based on firing patterns, and Ih properties were analyzed.

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  • Simulated synaptic currents and inhibitory postsynaptic potentials (IPSPs) were used to assess Ih's role in synaptic integration.

    • Main Results:

    • Three main firing patterns were identified: onset, adapting, and sustained neurons.
    • Onset and adapting neurons exhibited Ih-dependent depolarizing sag, a more depolarized resting potential, and lower input resistance.
    • Ih amplitude was largest in onset neurons, followed by adapting, and smallest in sustained neurons. Ih blockade affected temporal summation and abolished afterhyperpolarization and rebound spiking in onset neurons.

    Conclusions:

    • The Ih current is present in a majority of IC neurons, with varying properties across different neuronal types.
    • Ih significantly influences membrane properties and synaptic integration, particularly in onset and adapting neurons.
    • Ih plays a crucial role in enhancing precise temporal processing and auditory information analysis within the inferior colliculus.