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Sulfinimine-mediated asymmetric synthesis of beta-hydroxy alpha-amino phosphonates
Franklin A Davis1, Kavirayani R Prasad
1Department of Chemistry, Temple University, Philadelphia, Pennsylvania 19122, USA. fdavis@temple.edu
The Journal of Organic Chemistry
|September 13, 2003
Abstract:
The addition of potassium dialkyl phosphites to enantiopure O-protected alpha-hydroxy sulfinimine pseudoenantiomers affords beta-hydroxy alpha-amino phosphonates in good yield and de. The reaction exhibits a strong match-mismatch effect.