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Concise synthesis, preparative resolution, absolute configuration determination, and applications of an atropisomeric
Alan C Spivey1, Fujiang Zhu, Mark B Mitchell
1Department of Chemistry, University of Sheffield, Brook Hill, Sheffield S3 7HF, UK, Pfizer Global Research and Development-LaJolla, 10777 Science Center Drive, San Diego, California 92121, USA. a.c.spivey@imperial.ac.uk
The Journal of Organic Chemistry
|September 13, 2003
Abstract:
A new three-step synthesis and resolution of nucleophilic catalyst 1 suitable for large-scale preparation has been developed, and this catalyst has been shown to be effective for the kinetic resolution and asymmetric desymmetrization of a range of sec-alcohol substrates.