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Chest pain during use of bupropion as an aid in smoking cessation
1Netherlands Pharmacovigilance Centre Lareb, Goudsbloemvallei 7, 5237 MH 's-Hertogenbosch, The Netherlands. l.degraaf@lareb.nl
Aims:
To investigate the cause of chest pain during the use of bupropion as an aid to stop smoking.
Methods:
The Netherlands Pharmacovigilance Centre received 22 reports of chest pain, associated with the use of bupropion as an aid to smoking cessation. Additional information about long-term follow up was collected to analyze whether these complaints herald manifest cardiac disease.
Results:
All but one patient recovered after withdrawal of bupropion. Seven patients were additionally investigated and in six of them, a cardiac cause could be excluded. During long-term follow-up, no coronary heart diseases were diagnosed.
Conclusions:
These reports indicate that chest pain seems to be associated with the use of bupropion, but its origin remains unclear.
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