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Delta-F508 cystic fibrosis mutation is not linked to intussusception: implications for rotavirus vaccine

G Barnes1, A Srivastava, J Carlin

  • 1The Murdoch Childrens Research Institute, University of Melbourne, Royal Children's Hospital, Parkville, Australia. graeme.barnes@rch.org.au

Journal of Paediatrics and Child Health
|September 13, 2003
PubMed

Insights

The cystic fibrosis (CF) delta-F508 gene mutation does not predispose infants to intussusception. Therefore, CF screening is not relevant for rotavirus vaccine programs.

Area of Science:

  • Genetics
  • Pediatrics
  • Vaccinology

Background:

  • Intussusception is a serious intestinal condition in infants.
  • The delta-F508 mutation is the most common mutation causing cystic fibrosis (CF).
  • Concerns exist regarding potential links between CF mutations and intussusception, impacting rotavirus vaccine recommendations.

Purpose of the Study:

  • To investigate if the delta-F508 mutation in cystic fibrosis (CF) predisposes infants to intussusception.
  • To determine if identifying infants with the delta-F508 mutation could inform rotavirus vaccination strategies.

Main Methods:

  • Neonatal screening blood spots from 81 infants diagnosed with intussusception and 79 control infants were analyzed.
  • The presence of the CF delta-F508 gene mutation was tested in all blood specimens.

Main Results:

  • The prevalence of the delta-F508 mutation was found to be similar between infants with intussusception and the control group.
  • No statistically significant difference in mutation frequency was observed.

Conclusions:

  • Screening for the delta-F508 mutation at birth is unlikely to identify infants at increased risk for intussusception.
  • The findings suggest that testing for this CF mutation is not relevant for current rotavirus vaccine programs.
Abstract

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