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Entonox analgesia for prostatic biopsy
I G McIntyre1, A Dixon, M L Pantelides
1Department of Urology, Royal Bolton Hospital NHS Trust, Farnworth, Bolton, Lancashire, UK. iain@uroman.fsnet.co.uk
Prostate Cancer and Prostatic Diseases
|September 13, 2003
Summary
Entonox (nitrous oxide) significantly reduces pain during prostate biopsies. Patients receiving Entonox reported minimal pain compared to those breathing air, demonstrating its analgesic efficacy.
Area of Science:
- Urology
- Anesthesiology
- Pain Management
Background:
- Trans-rectal ultrasound (TRUS) guided prostate biopsy is a common procedure.
- Pain is frequently reported during prostate biopsies, potentially impacting patient tolerance and compliance.
- Effective analgesia is crucial for improving patient experience during TRUS-guided prostate biopsy.
Purpose of the Study:
- To evaluate the efficacy of Entonox (nitrous oxide) as a patient-administered analgesic during TRUS-guided prostate biopsy.
- To compare pain levels experienced by patients receiving Entonox versus those receiving air.
- To assess the impact of Entonox on patient-reported pain during prostate biopsy.
Main Methods:
- Prospective, randomized, double-blind study design.
- 50 patients undergoing sextant prostatic biopsies by a single surgeon.
- Patients inhaled either Entonox or air during the procedure.
- Pain was quantified using a 100 mm visual analogue pain scale.
Main Results:
- Patients breathing air reported moderate pain (median score 34).
- Patients breathing Entonox reported minimal pain (median score 11).
- Two Entonox users and one air user experienced severe pain, with no significant adverse events reported.
Conclusions:
- Prostate biopsy without analgesia results in moderate pain.
- Entonox provides significant pain reduction during TRUS-guided prostate biopsy.
- Entonox is an effective and well-tolerated analgesic option for this procedure.