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Translational Rabbit Model of Chronic Cardiac Pacing

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Pacemaker-lead-associated thrombosis in dogs: a multicenter retrospective study.

C McGrath¹, A Dixon¹, C Hirst¹

¹Langford Vets Small Animal Referral Hospital, University of Bristol, Langford House, Langford, Bristol, BS40 5DU, United Kingdom.

Journal of Veterinary Cardiology : the Official Journal of the European Society of Veterinary Cardiology

|August 4, 2023

Summary

This summary is machine-generated.

Pacemaker-lead-associated thrombosis (PLAT) affects 10.4% of dogs with transvenous pacemakers. This condition is linked to proteinuria and reduced survival times in canine patients.

Keywords:

Complications Proteinuria Thrombus Transvenous

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Area of Science:

Veterinary Cardiology
Thrombosis Research
Medical Device Complications

Background:

Pacemaker implantation is standard for bradyarrhythmias.
Pacemaker-lead-associated thrombosis (PLAT) affects 23.0-45.0% of humans with transvenous pacemakers.
The incidence of PLAT in dogs is currently unknown.

Purpose of the Study:

To determine the incidence of PLAT in dogs.
To identify risk factors and clinical outcomes associated with PLAT in dogs.
To evaluate the association between PLAT and proteinuria.

Main Methods:

A multicenter retrospective study involving 606 dogs undergoing pacemaker implantation (2012-2019).
Analysis of 260 dogs with transvenous pacemakers and echocardiographic follow-up.
Assessment of proteinuria using urine protein:creatinine ratio.

Main Results:

PLAT was identified in 10.4% (27/260) of dogs with transvenous pacemakers and echocardiographic follow-up.
Dogs with PLAT were more likely to have proteinuria at pacemaker implantation (100.0% vs. 40.4%).
Dogs with PLAT had significantly shorter survival times compared to those without PLAT (677 days vs. 1105 days).

Conclusions:

PLAT occurs in 10.4% of dogs following transvenous pacing.
PLAT in dogs is associated with proteinuria and reduced survival times.
PLAT can cause significant morbidity in canine patients.